Fever blisters are also called core sores, usually lasting between 10 and 14 days. The blisters are usually in groups and cause red, swollen, and sore wounds. They often develop near the mouth or other face parts but may also appear on the tongue or gums. The herpes simplex virus causes fever blisters. Approximately 90 percent of the world’s adult population has either HSV-1 or HSV-2. About 65 percent of the people in the United States have been exposed to HSV-1.

Even though fever blister flare-ups can heal independently, there are many effective ways to reduce the pain and promote healing. These include at-home remedies as well as prescription medications.